详细信息:α Integrin Blocking and IHC Kit
Chemicon Investigator Kits for Integrin Research are a cost-effective source of reagents for all investigators involved with this expanding field of study. The Chemicon Alpha Integrin Blocking and Immunohistochemistry Investigator Kit is designed for research on the functional activity and cellular localization of human integrin alpha subunits.
Integrins belong to a large family of cell surface proteins commonly referred to as glycoproteins. Integrins are composed of noncovalently associated alpha and beta subunits which make up heterodimers: the larger termed alpha chain and the smaller beta chain. At least 16 alpha subunits and 8 beta subunits are expressed, which can give rise to 22 different integrins. Integrins are thought to play critical roles in cell migration, differentiation, and survival. There is now considerable evidence that these transmembrane receptors play an important role in the regulation of gene expression and signal transduction. Excellent reviews of integrin structure, function, and ligand specificity may be found in: Hynes, R. 1992. Cell 69:11-25; Kramer, R. 1993. "Integrin Structure and Ligand Specificity in Cell-Matrix Interactions" in Molecular and Cellular Aspects of Basement Membranes. Academic Press.
Chemicon offers the Alpha Integrin Blocking and Immunohistochemistry Investigator Kit for studies of integrin alpha subunits. All kit reagents are also available in larger sizes. The reagents in this kit are not application specific but rather may be used in a variety of procedures, depending upon the needs of the individual investigator
